Of course, because Rodney would be the biggest rules lawyer ever, and totally minimax his stats with weird race/class classifications. ("I want to multiclass as a sorcerer/ranger half-dragon. And for my animal companion, a dire weasel.") While John would be vaguely confused by everything but the combat system, so all his characters would basically be Human Fighters but with different elaborate magical weapons and armor. John would keep attacking things indiscriminately ("Isn't that the point of this game?") while Rodney spends entire sessions arguing with Zelenka (who is totally the DM) about whether he's getting his fair share of XP and how the modifiers are supposed to stack, and also why he can't make up his own prestige classes ("Because it upsets the flavor, you insufferable man! There is no prestige class Time Lord in this setting!"). All the other players find excuses to send John and Rodney's characters off by themselves, so they can actually have fun. Eventually Zelenka just lets them get eaten by a tarrasque.

You can tell my boyfriend is president of the RPG club.